1t3g

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==Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL==
==Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL==
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<StructureSection load='1t3g' size='340' side='right' caption='[[1t3g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='1t3g' size='340' side='right'caption='[[1t3g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1t3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T3G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1t3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3G FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL1RAPL1, OPHN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3g OCA], [http://pdbe.org/1t3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t3g RCSB], [http://www.ebi.ac.uk/pdbsum/1t3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3g OCA], [https://pdbe.org/1t3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3g RCSB], [https://www.ebi.ac.uk/pdbsum/1t3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3g ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN]] Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:[http://omim.org/entry/300143 300143]]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:10757639</ref> <ref>PMID:16470793</ref>
 
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== Function ==
 
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[[http://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN]] May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.<ref>PMID:12783849</ref> <ref>PMID:15123616</ref>
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3g_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Khan, J A]]
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[[Category: Large Structures]]
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[[Category: Tong, L]]
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[[Category: Khan JA]]
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[[Category: Il-1r]]
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[[Category: Tong L]]
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[[Category: Il-1rapl]]
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[[Category: Membrane protein]]
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[[Category: Tir]]
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[[Category: Tlr]]
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Current revision

Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL

PDB ID 1t3g

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