Antifreeze protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:27, 26 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 3: Line 3:
== Function ==
== Function ==
-
'''Antifreeze protein''' (AFP) permits the survival of certain organisms in subzero temperatures. AFP binds to small ice crystals thus inhibiting their growth.<ref>PMID:15152087</ref><br />
+
'''Antifreeze protein''' (AFP) permits the survival of certain organisms in subzero temperatures. AFP binds to small ice crystals thus inhibiting their growth.<ref>PMID:15152087</ref>. There are 3 types of AFP which differ in the ice crusts face to which they bind<ref>PMID:33317024</ref>.<br />
 +
*'''AFP I''' is Ala-rich and alpha helical<br />
 +
*'''AFP II''' is Cys-rich and globular<br />
 +
*'''AFP III''' is globular<br />
* For winter flounder antifreeze protein type I see [[User:Mary Ball/AFP]].<br />
* For winter flounder antifreeze protein type I see [[User:Mary Ball/AFP]].<br />
* For snow flea antifreeze protein see [[Sandox 2pne]]
* For snow flea antifreeze protein see [[Sandox 2pne]]
Line 15: Line 18:
== Structural highlights ==
== Structural highlights ==
-
<scene name='46/460278/Cv/3'>AFP flat surface presents Thr residues</scene> at distances which match those of the primary prism plane of ice thus allowing for favorable interactions between the protein and ice crystals. Fungal antifreeze protein (PDB code [[3vn3]])<ref>PMID:22645341</ref> is shown.
+
<scene name='46/460278/Cv/4'>AFP flat surface presents Thr residues</scene> at distances which match those of the primary prism plane of ice thus allowing for favorable interactions between the protein and ice crystals. Fungal antifreeze protein (PDB code [[3vn3]])<ref>PMID:22645341</ref> is shown.
-
 
+
-
</StructureSection>
+
== 3D Structures of antifreeze protein ==
== 3D Structures of antifreeze protein ==
 +
[[Antifreeze protein 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*AFP I
+
-
 
+
-
**[[3p4g]] – MpAFP Ca-dependent residues 997-1318 – ''Marinomonas primoryensis''<BR />
+
-
**[[4kdv]], [[4kdw]] – MpAFP Igg-like domain residues 101-204<br />
+
-
**[[5ix9]] – MpAFP anchoring domain residues 12-187 (mutant) - NMR<br />
+
-
**[[5k8g]] – MpAFP peptide-binding domain residues 205-723 <br />
+
-
**[[5j6y]] – MpAFP PA14 domain residues 716-903 <br />
+
-
**[[5juh]] – MpAFP C-terminal domain residues 1386-1567 <br />
+
-
**[[3bog]], [[3boi]], [[2pne]] – AFP glycine-rich – ''Hypogastrura harveyi''<BR />
+
-
**[[1z2f]], [[1eww]] – sbAFP – spruce budworm – NMR<BR />
+
-
**[[1m8n]] – sbAFP<BR />
+
-
**[[1l0s]] – sbAFP (mutant) <BR />
+
-
**[[1j5b]] – wfAFP I (mutant) – winter flounder – NMR<BR />
+
-
**[[1wfa]], [[1wfb]], [[4ke2]] – wfAFP I <br />
+
-
**[[1ezg]] – TmAFP – ''Tenebrio molitor''<br />
+
-
**[[1l1i]] – TmAFP – NMR<br />
+
-
**[[1y03]], [[1y04]] - AFP – ''Myoxocephalus scorpius'' - NMR<br />
+
-
**[[3uyu]], [[3uyv]] – AFP residues 21-261 – arctic yeast<br />
+
-
**[[1n4i]] – AFP – ''Choristoneura fumiferana''<br />
+
-
**[[3vn3]] – AFP – snow mold fungus<br />
+
-
**[[4dt5]] – AFP – ''Rhagium inquisitor''<br />
+
-
**[[4nu2]], [[4nu3]], [[3wp9]] – AFP – ''Flavobacterium frigoris''<br />
+
-
**[[4nuh]] – AFP – ''Leucosporidium''<br />
+
-
**[[5b5h]] – AFP – ''Typhula ishikariensis''<br />
+
-
 
+
-
*AFP II
+
-
 
+
-
**[[2py2]] – AFP II – Atlantic herring<BR />
+
-
**[[2afp]] – AFP II – sea raven - NMR<BR />
+
-
**[[2zib]] – AFP II Ca-independent – ''Brachyopsis rostratus''
+
-
 
+
-
*AFP III
+
-
**[[3qf6]] – opAFP III – ocean pout – Neutron<BR />
 
-
**[[1ops]], [[4ny6]] – opAFP III<BR />
 
-
**[[1hg7]], [[1b7i]], [[1b7j]], [[2ame]], [[1b7k]], [[1ekl]], [[1jab]], [[1msj]], [[2jia]], [[2msj]], [[3ame]], [[4ame]], [[6ame]], [[7ame]], [[8ame]], [[8msi]], [[9ame]], [[2spg]], [[9msi]], [[2msi]], [[3msi]], [[4msi]], [[5msi]], [[6msi]], [[7msi]], [[1ame]], [[1msi]], [[1gzi]] – opAFP III (mutant) <BR />
 
-
**[[1kde]], [[1kdf]] - opAFP III (mutant) - NMR<BR />
 
-
**[[1ucs]], [[4ur4]], [[4ur6]] – aepAFP III – Atlantic eel pout<BR />
 
-
**[[3nla]], [[3rdn]] - aepAFP III N terminal]] - NMR<BR />
 
-
**[[1c89]], [[1c8a]] – AFP III – ''Pachycara brachycephalum'' - NMR<BR />
 
-
**[[2lx2]], [[2lx3]] – AFP III – ''Zoarces elongatus'' - NMR<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Fungal antifreeze protein complex with ethylene glycol (PDB code 3vn3)

Drag the structure with the mouse to rotate

References

  1. ↑ Jorov A, Zhorov BS, Yang DS. Theoretical study of interaction of winter flounder antifreeze protein with ice. Protein Sci. 2004 Jun;13(6):1524-37. PMID:15152087 doi:http://dx.doi.org/10.1110/ps.04641104
  2. ↑ Eskandari A, Leow TC, Rahman MBA, Oslan SN. Antifreeze Proteins and Their Practical Utilization in Industry, Medicine, and Agriculture. Biomolecules. 2020 Dec 9;10(12):1649. PMID:33317024 doi:10.3390/biom10121649
  3. ↑ Kondo H, Hanada Y, Sugimoto H, Hoshino T, Garnham CP, Davies PL, Tsuda S. Ice-binding site of snow mold fungus antifreeze protein deviates from structural regularity and high conservation. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9360-5. Epub 2012 May 29. PMID:22645341 doi:10.1073/pnas.1121607109

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Antifreeze_protein"
Personal tools