5zhg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human group C rotavirus VP8*s recognize type A histo-blood group antigens as ligands== | |
| - | + | <StructureSection load='5zhg' size='340' side='right'caption='[[5zhg]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zhg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_C/Bristol Human rotavirus C/Bristol]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZHG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.799Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhg OCA], [https://pdbe.org/5zhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zhg RCSB], [https://www.ebi.ac.uk/pdbsum/5zhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhg ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/VP4_ROTHC VP4_ROTHC] Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors (By similarity). Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm (By similarity). VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human rotavirus C/Bristol]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Duan Z]] | ||
| + | [[Category: Sun X]] | ||
Current revision
Human group C rotavirus VP8*s recognize type A histo-blood group antigens as ligands
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