2ftx

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[[Image:2ftx.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain==
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|PDB= 2ftx |SIZE=350|CAPTION= <scene name='initialview01'>2ftx</scene>, resolution 1.90&Aring;
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<StructureSection load='2ftx' size='340' side='right'caption='[[2ftx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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<table><tr><td colspan='2'>[[2ftx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FTX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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|GENE= YER018C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), YMR117C, YM9718.16C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YER018C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), YMR117C, YM9718.16C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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|RELATEDENTRY=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ftx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftx OCA], [https://pdbe.org/2ftx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ftx RCSB], [https://www.ebi.ac.uk/pdbsum/2ftx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ftx ProSAT]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ftx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftx OCA], [http://www.ebi.ac.uk/pdbsum/2ftx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ftx RCSB]</span>
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</table>
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}}
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== Function ==
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[[https://www.uniprot.org/uniprot/SPC25_YEAST SPC25_YEAST]] Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.<ref>PMID:11266451</ref> <ref>PMID:12514103</ref> [[https://www.uniprot.org/uniprot/SPC24_YEAST SPC24_YEAST]] Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.<ref>PMID:11266451</ref> <ref>PMID:11952896</ref> <ref>PMID:12514103</ref>
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'''Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2FTX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTX OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftx_consurf.spt"</scriptWhenChecked>
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[[Category: Protein complex]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Saccharomyces cerevisiae]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Harrison, S C.]]
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</jmolCheckbox>
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[[Category: Wei, R R.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ftx ConSurf].
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[[Category: alpha-beta]]
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<div style="clear:both"></div>
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[[Category: coiled-coil]]
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== References ==
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[[Category: complex]]
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<references/>
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__TOC__
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:07:38 2008''
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</StructureSection>
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[[Category: Atcc 18824]]
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[[Category: Large Structures]]
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[[Category: Harrison, S C]]
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[[Category: Wei, R R]]
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[[Category: Alpha-beta]]
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[[Category: Coiled-coil]]
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[[Category: Complex]]
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[[Category: Protein binding]]
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[[Category: Structural protein]]

Current revision

Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain

PDB ID 2ftx

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