2fv8

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[[Image:2fv8.gif|left|200px]]
 
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{{Structure
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==The crystal structure of RhoB in the GDP-bound state==
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|PDB= 2fv8 |SIZE=350|CAPTION= <scene name='initialview01'>2fv8</scene>, resolution 1.90&Aring;
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<StructureSection load='2fv8' size='340' side='right'caption='[[2fv8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
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<table><tr><td colspan='2'>[[2fv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FV8 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= RHOB, ARH6, ARHB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fv8 OCA], [https://pdbe.org/2fv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fv8 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fv8 OCA], [http://www.ebi.ac.uk/pdbsum/2fv8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fv8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RHOB_HUMAN RHOB_HUMAN] Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.<ref>PMID:9478917</ref> <ref>PMID:10508588</ref> <ref>PMID:15226397</ref> <ref>PMID:16236794</ref> <ref>PMID:21373644</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fv8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fv8 ConSurf].
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<div style="clear:both"></div>
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'''The crystal structure of RhoB in the GDP-bound state'''
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
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==About this Structure==
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== References ==
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2FV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV8 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Delft, F von.]]
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[[Category: Doyle D]]
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[[Category: Doyle, D.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gorrec F]]
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[[Category: Gorrec, F.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Schoch G]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Smee C]]
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[[Category: Schoch, G.]]
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[[Category: Soundararajan M]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom M]]
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[[Category: Soundararajan, M.]]
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[[Category: Turnbull AP]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Turnbull, A P.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: gdp/gtp binding]]
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[[Category: gtp hydrolysis]]
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[[Category: rhob]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:05 2008''
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Current revision

The crystal structure of RhoB in the GDP-bound state

PDB ID 2fv8

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