2fw3

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[[Image:2fw3.gif|left|200px]]
 
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{{Structure
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==Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326==
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|PDB= 2fw3 |SIZE=350|CAPTION= <scene name='initialview01'>2fw3</scene>, resolution 2.50&Aring;
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<StructureSection load='2fw3' size='340' side='right'caption='[[2fw3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BUI:(3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUI</scene>
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<table><tr><td colspan='2'>[[2fw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FW3 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUI:(3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUI</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fw3 OCA], [https://pdbe.org/2fw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2fw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fw3 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fw3 OCA], [http://www.ebi.ac.uk/pdbsum/2fw3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fw3 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CPT2_RAT CPT2_RAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fw3 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326'''
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==See Also==
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*[[Carnitine palmitoyltransferase|Carnitine palmitoyltransferase]]
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__TOC__
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==Overview==
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</StructureSection>
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Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
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[[Category: Large Structures]]
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==About this Structure==
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2FW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW3 OCA].
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==Reference==
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A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615901 16615901]
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[[Category: Carnitine O-palmitoyltransferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Banner DW]]
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[[Category: Banner, D W.]]
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[[Category: Benz J]]
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[[Category: Benz, J.]]
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[[Category: Chomienne O]]
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[[Category: Chomienne, O.]]
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[[Category: De Roo E]]
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[[Category: Gsell, B.]]
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[[Category: Gsell B]]
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[[Category: Hennig, M.]]
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[[Category: Hennig M]]
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[[Category: Mueller, F.]]
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[[Category: Mueller F]]
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[[Category: Roo, E De.]]
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[[Category: Rufer AC]]
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[[Category: Rufer, A C.]]
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[[Category: Stihle M]]
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[[Category: Stihle, M.]]
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[[Category: Thoma R]]
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[[Category: Thoma, R.]]
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[[Category: central six-stranded beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:24 2008''
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Current revision

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326

PDB ID 2fw3

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