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2fye

From Proteopedia

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[[Image:2fye.gif|left|200px]]
 
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{{Structure
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==Mutant Human Cathepsin S with irreversible inhibitor CRA-14013==
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|PDB= 2fye |SIZE=350|CAPTION= <scene name='initialview01'>2fye</scene>, resolution 2.200&Aring;
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<StructureSection load='2fye' size='340' side='right'caption='[[2fye]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BCQ:N-[(1R)-1-[({[(5S)-3,5-DIMETHYL-2,5-DIHYDROISOXAZOL-4-YL]METHYL}SULFONYL)METHYL]-2-OXO-2-({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)ETHYL]MORPHOLINE-4-CARBOXAMIDE'>BCQ</scene>
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<table><tr><td colspan='2'>[[2fye]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FYE FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCQ:N-[(1R)-1-[({[(5S)-3,5-DIMETHYL-2,5-DIHYDROISOXAZOL-4-YL]METHYL}SULFONYL)METHYL]-2-OXO-2-({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)ETHYL]MORPHOLINE-4-CARBOXAMIDE'>BCQ</scene></td></tr>
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|GENE=
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fye OCA], [https://pdbe.org/2fye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fye RCSB], [https://www.ebi.ac.uk/pdbsum/2fye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fye ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fye OCA], [http://www.ebi.ac.uk/pdbsum/2fye PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fye RCSB]</span>
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== Function ==
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}}
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[[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fye_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fye ConSurf].
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<div style="clear:both"></div>
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'''Mutant Human Cathepsin S with irreversible inhibitor CRA-14013'''
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2FYE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYE OCA].
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[[Category: Cathepsin S]]
[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Somoza, J R.]]
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[[Category: Somoza, J R]]
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[[Category: 14013]]
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[[Category: Cysteine protease]]
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[[Category: cysteine protease]]
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[[Category: Drug design]]
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[[Category: drug design]]
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[[Category: Hydrolase]]
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[[Category: papain]]
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[[Category: Papain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:09:18 2008''
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Current revision

Mutant Human Cathepsin S with irreversible inhibitor CRA-14013

PDB ID 2fye

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