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1tv5

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==Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor==
==Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor==
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<StructureSection load='1tv5' size='340' side='right' caption='[[1tv5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='1tv5' size='340' side='right'caption='[[1tv5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1tv5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1tv5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TV5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A26:(2Z)-2-CYANO-3-HYDROXY-N-[4-(TRIFLUOROMETHYL)PHENYL]BUT-2-ENAMIDE'>A26</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=N8E:3,6,9,12,15-PENTAOXATRICOSAN-1-OL'>N8E</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dhod ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A26:(2Z)-2-CYANO-3-HYDROXY-N-[4-(TRIFLUOROMETHYL)PHENYL]BUT-2-ENAMIDE'>A26</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=N8E:3,6,9,12,15-PENTAOXATRICOSAN-1-OL'>N8E</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv5 OCA], [http://pdbe.org/1tv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tv5 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv5 OCA], [https://pdbe.org/1tv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tv5 RCSB], [https://www.ebi.ac.uk/pdbsum/1tv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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[https://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plafa]]
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[[Category: Large Structures]]
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[[Category: Clardy, J]]
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[[Category: Plasmodium falciparum]]
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[[Category: Hurt, D E]]
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[[Category: Clardy J]]
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[[Category: Widom, J]]
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[[Category: Hurt DE]]
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[[Category: Alpha-beta barrel]]
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[[Category: Widom J]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]
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Current revision

Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

PDB ID 1tv5

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