1u7k

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==Structure of a hexameric N-terminal domain from murine leukemia virus capsid==
==Structure of a hexameric N-terminal domain from murine leukemia virus capsid==
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<StructureSection load='1u7k' size='340' side='right' caption='[[1u7k]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='1u7k' size='340' side='right'caption='[[1u7k]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u7k]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Akr_(endogenous)_murine_leukemia_virus Akr (endogenous) murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U7K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u7k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/AKR_(endogenous)_murine_leukemia_virus AKR (endogenous) murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U7K FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11791 AKR (endogenous) murine leukemia virus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7k OCA], [http://pdbe.org/1u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u7k RCSB], [http://www.ebi.ac.uk/pdbsum/1u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u7k ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7k OCA], [https://pdbe.org/1u7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u7k RCSB], [https://www.ebi.ac.uk/pdbsum/1u7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u7k ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/GAG_MLVAV GAG_MLVAV]] Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release (By similarity). Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Nucleocapsid protein p10 is involved in the packaging and encapsidation of two copies of the genome. Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome. This binding is dependent on genome dimerization (By similarity).
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u7k_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u7/1u7k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Gag polyprotein|Gag polyprotein]]
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Haire, L F]]
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[[Category: Large Structures]]
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[[Category: Mortuza, G B]]
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[[Category: Haire LF]]
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[[Category: Smerdon, S J]]
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[[Category: Mortuza GB]]
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[[Category: Stevens, A]]
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[[Category: Smerdon SJ]]
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[[Category: Stoye, J P]]
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[[Category: Stevens A]]
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[[Category: Taylor, I A]]
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[[Category: Stoye JP]]
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[[Category: Capsid]]
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[[Category: Taylor IA]]
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[[Category: Viral protein]]
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Current revision

Structure of a hexameric N-terminal domain from murine leukemia virus capsid

PDB ID 1u7k

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