1tzo

<StructureSection load='1tzo' size='340' side='right' caption='[[1tzo]], [[Resolution|resolution]] 3.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[1tzo]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_a2012 Bacillus anthracis a2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TZO FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sht|1sht]], [[1tzn|1tzn]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=191218 Bacillus anthracis A2012])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tzo OCA], [http://pdbe.org/1tzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tzo RCSB], [http://www.ebi.ac.uk/pdbsum/1tzo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tzo ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

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== Publication Abstract from PubMed ==

After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later undergoes pH-dependent conversion to a pore, mediating translocation of the edema and lethal factors to the cytosol. We describe structures of the prepore (3.6 A) and a prepore:receptor complex (4.3 A) that reveal the location of pore-forming loops and an unexpected interaction of the receptor with the pore-forming domain. Lower pH is required for prepore-to-pore conversion in the presence of the receptor, indicating that this interaction regulates pH-dependent pore formation. We present an example of a receptor negatively regulating pH-dependent membrane insertion.

Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.,Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51. Epub 2004 Aug 23. PMID:15326297<ref>PMID:15326297</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1tzo" style="background-color:#fffaf0;"></div>

==See Also==

*[[Anthrax protective antigen|Anthrax protective antigen]]

== References ==

<references/>

[[Category: Bacillus anthracis a2012]]

[[Category: Collier, R J]]

[[Category: Lacy, D B]]

[[Category: Melnyk, R A]]

[[Category: Wigelsworth, D J]]

[[Category: Heptamer]]

[[Category: Toxin]]