2g2y

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[[Image:2g2y.gif|left|200px]]
 
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{{Structure
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==Structure of E.coli FabD complexed with malonate==
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|PDB= 2g2y |SIZE=350|CAPTION= <scene name='initialview01'>2g2y</scene>, resolution 2.26&Aring;
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<StructureSection load='2g2y' size='340' side='right'caption='[[2g2y]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>
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<table><tr><td colspan='2'>[[2g2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2Y FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Acyl-carrier-protein]_S-malonyltransferase [Acyl-carrier-protein] S-malonyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.39 2.3.1.39] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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|GENE= FabD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2y OCA], [https://pdbe.org/2g2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2y RCSB], [https://www.ebi.ac.uk/pdbsum/2g2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2y ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2g2o|2G2O]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2y OCA], [http://www.ebi.ac.uk/pdbsum/2g2y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g2y RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/FABD_ECOLI FABD_ECOLI]
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== Evolutionary Conservation ==
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'''Structure of E.coli FabD complexed with malonate'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/2g2y_consurf.spt"</scriptWhenChecked>
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Malonyl-CoA-acyl carrier protein transacylase (FabD; EC 2.3.1.39) is a key enzyme in the fatty-acid biosynthesis pathway of bacteria, catalyzing the transfer of a malonyl moiety from malonyl-CoA to holo acyl carrier protein (ACP), generating malonyl-ACP and free CoASH. Malonyl-ACP, which is the product of this reaction, is the key building block for de novo fatty-acid biosynthesis. Various binary complex structures of the Escherichia coli enzyme are presented, including that of the natural substrate malonyl-CoA, indicating the functional role of the highly conserved amino acids Gln11, Ser92, Arg117 and His201 and the stabilizing function of the preformed oxyanion hole during the enzymatic reaction. Based on the presented structural data, a possible new catalytic enzyme mechanism is discussed. The data obtained could be used in aiding the process of rational inhibitor design.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2G2Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2Y OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g2y ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography., Oefner C, Schulz H, D'Arcy A, Dale GE, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):613-8. Epub 2006, May 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16699188 16699188]
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: [Acyl-carrier-protein] S-malonyltransferase]]
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[[Category: Oefner C]]
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[[Category: Oefner, C.]]
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[[Category: complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:11:07 2008''
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Current revision

Structure of E.coli FabD complexed with malonate

PDB ID 2g2y

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