6ccg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure MBD3 MBD domain in complex with methylated CpG DNA== | |
| + | <StructureSection load='6ccg' size='340' side='right'caption='[[6ccg]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ccg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CCG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ccg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ccg OCA], [https://pdbe.org/6ccg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ccg RCSB], [https://www.ebi.ac.uk/pdbsum/6ccg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ccg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MBD3_HUMAN MBD3_HUMAN] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.<ref>PMID:9774669</ref> <ref>PMID:10947852</ref> <ref>PMID:12124384</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Liu | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Tempel | + | [[Category: Bountra C]] |
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Liu K]] | ||
| + | [[Category: Min J]] | ||
| + | [[Category: Tempel W]] | ||
Current revision
Crystal structure MBD3 MBD domain in complex with methylated CpG DNA
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