6cqf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HPK1 in complex an inhibitor G1858== | |
| - | + | <StructureSection load='6cqf' size='340' side='right'caption='[[6cqf]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6cqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CQF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.246Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F97:N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine'>F97</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cqf OCA], [https://pdbe.org/6cqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cqf RCSB], [https://www.ebi.ac.uk/pdbsum/6cqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cqf ProSAT]</span></td></tr> |
| - | [[Category: Chan | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref> |
| - | [[Category: Mortara | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chan BK]] | ||
| + | [[Category: Franke Y]] | ||
| + | [[Category: Lehoux I]] | ||
| + | [[Category: Mortara K]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Wu P]] | ||
Current revision
Crystal structure of HPK1 in complex an inhibitor G1858
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Categories: Homo sapiens | Large Structures | Chan BK | Franke Y | Lehoux I | Mortara K | Wang W | Wu P
