6csu

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m (Protected "6csu" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6csu is ON HOLD
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==The structure of the Cep63-Cep152 heterotetrameric complex==
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<StructureSection load='6csu' size='340' side='right'caption='[[6csu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6csu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CSU FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6csu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csu OCA], [https://pdbe.org/6csu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6csu RCSB], [https://www.ebi.ac.uk/pdbsum/6csu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6csu ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CE152_HUMAN CE152_HUMAN] Seckel syndrome;Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CE152_HUMAN CE152_HUMAN] Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.<ref>PMID:21059844</ref> <ref>PMID:20852615</ref> <ref>PMID:21131973</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ahn JI]]
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[[Category: Chen Y]]
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[[Category: Kim TS]]
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[[Category: Lee E]]
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[[Category: Lee KS]]
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[[Category: Park JE]]
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[[Category: Zhang L]]

Current revision

The structure of the Cep63-Cep152 heterotetrameric complex

PDB ID 6csu

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OCA

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