This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6csw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6csw is ON HOLD Authors: dos Reis, C.V., de Souza, G.P., Counago, R.M., Chiodi, C.G., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira...)
Current revision (15:10, 4 October 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6csw is ON HOLD
+
==Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor==
 +
<StructureSection load='6csw' size='340' side='right'caption='[[6csw]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6csw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CSW FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FBY:(7R)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5H)-one'>FBY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6csw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csw OCA], [https://pdbe.org/6csw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6csw RCSB], [https://www.ebi.ac.uk/pdbsum/6csw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6csw ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
-
Authors: dos Reis, C.V., de Souza, G.P., Counago, R.M., Chiodi, C.G., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira, M., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M.
+
==See Also==
-
 
+
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-
Description: Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Elkins, J.M]]
+
__TOC__
-
[[Category: Ferreira, M]]
+
</StructureSection>
-
[[Category: Edwards, A.M]]
+
[[Category: Homo sapiens]]
-
[[Category: Gama, F]]
+
[[Category: Large Structures]]
-
[[Category: Arruda, P]]
+
[[Category: Arruda P]]
-
[[Category: Massirer, K.B]]
+
[[Category: Azevedo A]]
-
[[Category: Guimaraes, C]]
+
[[Category: Chiodi CG]]
-
[[Category: Chiodi, C.G]]
+
[[Category: Counago RM]]
-
[[Category: Mascarello, A]]
+
[[Category: Edwards AM]]
-
[[Category: Azevedo, A]]
+
[[Category: Elkins JM]]
-
[[Category: Counago, R.M]]
+
[[Category: Ferreira M]]
-
[[Category: De Souza, G.P]]
+
[[Category: Gama F]]
-
[[Category: Dos Reis, C.V]]
+
[[Category: Guimaraes C]]
 +
[[Category: Mascarello A]]
 +
[[Category: Massirer KB]]
 +
[[Category: De Souza GP]]
 +
[[Category: Dos Reis CV]]

Current revision

Crystal Structure of the Human vaccinia-related kinase bound to a N-methyl-N-propyl-dihydropteridine inhibitor

PDB ID 6csw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6csw"
Personal tools