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| - | [[Image:2g4s.gif|left|200px]] | |
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| - | {{Structure
| + | ==Anomalous substructure of NBR1PB1== |
| - | |PDB= 2g4s |SIZE=350|CAPTION= <scene name='initialview01'>2g4s</scene>, resolution 2.15Å
| + | <StructureSection load='2g4s' size='340' side='right'caption='[[2g4s]], [[Resolution|resolution]] 2.15Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | + | <table><tr><td colspan='2'>[[2g4s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G4S FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> |
| - | |GENE= NBR1,1A13B, KIAA0049, M17S2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | |DOMAIN=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g4s OCA], [https://pdbe.org/2g4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g4s RCSB], [https://www.ebi.ac.uk/pdbsum/2g4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g4s ProSAT]</span></td></tr> |
| - | |RELATEDENTRY=[[2g4h|2G4H]], [[2g4i|2G4I]], [[2g4j|2G4J]], [[2g4k|2G4K]], [[2g4l|2G4L]], [[2g4m|2G4M]], [[2g4n|2G4N]], [[2g4o|2G4O]], [[2g4p|2G4P]], [[2g4q|2G4Q]], [[2g4r|2G4R]], [[2g4t|2G4T]], [[2g4u|2G4U]], [[2g4v|2G4V]], [[2g4w|2G4W]], [[2g4x|2G4X]], [[2g4y|2G4Y]], [[2g4z|2G4Z]], [[2g51|2G51]], [[2g52|2G52]], [[2g55|2G55]]
| + | </table> |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g4s OCA], [http://www.ebi.ac.uk/pdbsum/2g4s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g4s RCSB]</span>
| + | == Function == |
| - | }}
| + | [https://www.uniprot.org/uniprot/NBR1_HUMAN NBR1_HUMAN] Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.<ref>PMID:19250911</ref> |
| - | | + | == References == |
| - | '''Anomalous substructure of NBR1PB1'''
| + | <references/> |
| - | | + | __TOC__ |
| - | | + | </StructureSection> |
| - | ==Overview==
| + | |
| - | 23 different crystal forms of 19 different biological macromolecules were examined with respect to their anomalously scattering substructures using diffraction data collected at a wavelength of 2.0 A (6.2 keV). In more than 90% of the cases the substructure was found to contain more than just the protein S atoms. The data presented suggest that chloride, sulfate, phosphate or metal ions from the buffer or even from the purification protocol are frequently bound to the protein molecule and that these ions are often overlooked, especially if they are not bound at full occupancy. Thus, in order to fully describe the macromolecule under study, it seems desirable that any structure determination be complemented with a long-wavelength data set.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 2G4S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G4S OCA].
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| - | | + | |
| - | ==Reference== | + | |
| - | On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths., Mueller-Dieckmann C, Panjikar S, Schmidt A, Mueller S, Kuper J, Geerlof A, Wilmanns M, Singh RK, Tucker PA, Weiss MS, Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):366-80. Epub 2007, Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17327674 17327674]
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| | [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| - | [[Category: Single protein]] | + | [[Category: Large Structures]] |
| - | [[Category: Mueller-Dieckmann, C.]] | + | [[Category: Mueller-Dieckmann C]] |
| - | [[Category: Weiss, M S.]] | + | [[Category: Weiss MS]] |
| - | [[Category: anomalous substructure of nbr1pb1]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:11:49 2008''
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