6aqu

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==Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase: The M183L mutant==
==Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase: The M183L mutant==
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<StructureSection load='6aqu' size='340' side='right' caption='[[6aqu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='6aqu' size='340' side='right'caption='[[6aqu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6aqu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AQU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6aqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AQU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aqu OCA], [http://pdbe.org/6aqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aqu RCSB], [http://www.ebi.ac.uk/pdbsum/6aqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aqu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aqu OCA], [https://pdbe.org/6aqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aqu RCSB], [https://www.ebi.ac.uk/pdbsum/6aqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aqu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PNPH_PLAF7 PNPH_PLAF7] As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:18957439, PubMed:14982926, PubMed:16131758, PubMed:19575810, PubMed:24416224, PubMed:29440412). Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyguanosine and guanosine (PubMed:14982926, PubMed:16131758, PubMed:19575810). Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Generates hypoxanthine from both the purine salvage pathway and from polyamine metabolism which is required for nucleic acids synthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Has no activity towards adenosine (By similarity).[UniProtKB:Q8T9Z7]<ref>PMID:14982926</ref> <ref>PMID:16131758</ref> <ref>PMID:18957439</ref> <ref>PMID:19575810</ref> <ref>PMID:24416224</ref> <ref>PMID:29440412</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6aqu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6aqu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Purine-nucleoside phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Bonanno, J B]]
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[[Category: Ducati, R G]]
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[[Category: Harijan, R K]]
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[[Category: Namanja-Magliano, H A]]
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[[Category: Schramm, V L]]
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[[Category: Drug resistant pnp]]
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Pnp mutation]]
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[[Category: Almo SC]]
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[[Category: Transferase]]
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[[Category: Bonanno JB]]
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[[Category: Ducati RG]]
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[[Category: Harijan RK]]
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[[Category: Namanja-Magliano HA]]
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[[Category: Schramm VL]]

Current revision

Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase: The M183L mutant

PDB ID 6aqu

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