6c06

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==Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin==
==Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin==
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<StructureSection load='6c06' size='340' side='right' caption='[[6c06]], [[Resolution|resolution]] 5.15&Aring;' scene=''>
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<SX load='6c06' size='340' side='right' viewer='molstar' caption='[[6c06]], [[Resolution|resolution]] 5.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c06]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C06 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c06]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C06 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FI8:Fidaxomicin'>FI8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6bzo|6bzo]], [[6c04|6c04]], [[6c05|6c05]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FI8:[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-[[(3~{E},5~{E},8~{S},9~{E},11~{S},12~{R},13~{E},15~{E},18~{S})-12-[(2~{R},3~{S},4~{R},5~{S})-6,6-dimethyl-5-(2-methylpropanoyloxy)-3,4-bis(oxidanyl)oxan-2-yl]oxy-11-ethyl-9,13,15-trimethyl-8-oxidanyl-18-[(1~{R})-1-oxidanylethyl]-2-oxidanylidene-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-5-methoxy-2-methyl-4-oxidanyl-oxan-3-yl]+3,5-bis(chloranyl)-2-ethyl-4,6-bis(oxidanyl)benzoate'>FI8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c06 OCA], [https://pdbe.org/6c06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c06 RCSB], [https://www.ebi.ac.uk/pdbsum/6c06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c06 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c06 OCA], [http://pdbe.org/6c06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c06 RCSB], [http://www.ebi.ac.uk/pdbsum/6c06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c06 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A045IP01_MYCTX A0A045IP01_MYCTX]] Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.[HAMAP-Rule:MF_01483] [[http://www.uniprot.org/uniprot/A0A0T9N9K3_MYCTX A0A0T9N9K3_MYCTX]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.[HAMAP-Rule:MF_00366][SAAS:SAAS00298387] [[http://www.uniprot.org/uniprot/A0A045J8T1_MYCTX A0A045J8T1_MYCTX]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00059] [[http://www.uniprot.org/uniprot/A0A045J9E2_MYCTX A0A045J9E2_MYCTX]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[RuleBase:RU004279][SAAS:SAAS00365746] [[http://www.uniprot.org/uniprot/V9Z879_MYCTX V9Z879_MYCTX]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[RuleBase:RU363031] [[http://www.uniprot.org/uniprot/A0A045HD00_MYCTX A0A045HD00_MYCTX]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.[SAAS:SAAS00535554]
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[https://www.uniprot.org/uniprot/RPOA_MYCTU RPOA_MYCTU] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00059]<ref>PMID:22570422</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c06" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c06" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Campbell, E A]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Chen, J]]
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[[Category: Boyaci Selcuk H]]
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[[Category: Darst, S A]]
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[[Category: Campbell EA]]
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[[Category: Lilic, M]]
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[[Category: Chen J]]
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[[Category: Selcuk, H Boyaci]]
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[[Category: Darst SA]]
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[[Category: Antibiotic]]
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[[Category: Lilic M]]
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[[Category: Initiation]]
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[[Category: Switch region inhibitor]]
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[[Category: Transcription]]
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[[Category: Transcription-antibiotic complex]]
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Current revision

Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin

6c06, resolution 5.15Å

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OCA

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