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6cnh

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==Human PRPF4B in complex with Rebastinib==
==Human PRPF4B in complex with Rebastinib==
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<StructureSection load='6cnh' size='340' side='right' caption='[[6cnh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='6cnh' size='340' side='right'caption='[[6cnh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cnh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CNH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cnh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CNH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnh OCA], [http://pdbe.org/6cnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cnh RCSB], [http://www.ebi.ac.uk/pdbsum/6cnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cnh OCA], [https://pdbe.org/6cnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cnh RCSB], [https://www.ebi.ac.uk/pdbsum/6cnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cnh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN]] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
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[https://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Arruda, P]]
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[[Category: Large Structures]]
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[[Category: Counago, R M]]
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[[Category: Arruda P]]
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[[Category: Edwards, A M]]
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[[Category: Counago RM]]
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[[Category: Elkins, J M]]
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[[Category: Edwards AM]]
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[[Category: Fala, A M]]
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[[Category: Elkins JM]]
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[[Category: Gileadi, O]]
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[[Category: Fala AM]]
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[[Category: Godoi, P H.C]]
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[[Category: Gileadi O]]
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[[Category: Guimaraes, C R.W]]
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[[Category: Godoi PHC]]
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[[Category: Massirer, K B]]
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[[Category: Guimaraes CRW]]
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[[Category: Ramos, P Z]]
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[[Category: Massirer KB]]
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[[Category: Righetto, G L]]
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[[Category: Ramos PZ]]
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[[Category: Structural genomic]]
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[[Category: Righetto GL]]
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[[Category: Salmazo, A P.T]]
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[[Category: Salmazo APT]]
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[[Category: Santiago, A S]]
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[[Category: Santiago AS]]
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[[Category: Silva, P N.B]]
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[[Category: Silva PNB]]
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[[Category: Dcc2036]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Human PRPF4B in complex with Rebastinib

PDB ID 6cnh

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