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4c8r

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==Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)==
==Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)==
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<StructureSection load='4c8r' size='340' side='right' caption='[[4c8r]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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<StructureSection load='4c8r' size='340' side='right'caption='[[4c8r]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c8r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c8r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6YT:N-(3-HYDROXYPICOLINOYL)-S-(PYRIDIN-2-YLMETHYL)-L-CYSTEINE'>6YT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Gamma-butyrobetaine_dioxygenase Gamma-butyrobetaine dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.1 1.14.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6YT:N-(3-HYDROXYPICOLINOYL)-S-(PYRIDIN-2-YLMETHYL)-L-CYSTEINE'>6YT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8r OCA], [http://pdbe.org/4c8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8r RCSB], [http://www.ebi.ac.uk/pdbsum/4c8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8r OCA], [https://pdbe.org/4c8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8r RCSB], [https://www.ebi.ac.uk/pdbsum/4c8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BODG_HUMAN BODG_HUMAN]] Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
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[https://www.uniprot.org/uniprot/BODG_HUMAN BODG_HUMAN] Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4c8r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4c8r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gamma-butyrobetaine dioxygenase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Chowdhury, R]]
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[[Category: Chowdhury R]]
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[[Category: Kochan, G T]]
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[[Category: Kochan GT]]
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[[Category: McDonough, M A]]
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[[Category: McDonough MA]]
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[[Category: Rydzik, A M]]
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[[Category: Rydzik AM]]
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[[Category: Schofield, C J]]
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[[Category: Schofield CJ]]
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[[Category: 2-oxoglutarate]]
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[[Category: Dioxygenase 1]]
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[[Category: Dsbh]]
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[[Category: Facial triad]]
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[[Category: Gamma-butyrobetaine]]
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[[Category: Hydroxylase]]
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[[Category: Iron]]
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[[Category: Non-heme]]
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[[Category: Oxidoreductase]]
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Current revision

Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)

PDB ID 4c8r

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