BAG protein

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== Function ==
== Function ==
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The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>
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The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') or '''BAG-family molecular chaperone protein''' perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>
== Structural highlights ==
== Structural highlights ==
BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
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</StructureSection>
 
==3D structures of BAG family proteins==
==3D structures of BAG family proteins==
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[[BAG family proteins 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''BAG-1'''
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**[[1i6z]] – mBAG-1 BAG domain - mouse<br />
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**[[2lwp]] – mBAG-1 BAG domain - NMR<br />
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**[[1t7s]] – BAG-1 BAG domain – ''Caenorhabditis elegans''<br />
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**[[4hwc]] – AtBAG-1 BAG domain – ''Arabidopsis thaliana''<br />
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**[[1wxv]] – hBAG-1 BAG domain – human - NMR<br />
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*''BAG-1 complex with HSC70''
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**[[3fzf]] – hBAG-1 BAG domain + HSC70 ATPase domain + ATP<br />
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**[[3fzh]], [[3fzk]], [[3fzl]], [[3fzm]], [[3ldq]], [[3m3z]] – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor<br />
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**[[4hwi]] – AtBAG-1 BAG domain + HSC70 ATPase domain <br />
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**[[1hx1]] – BAG-1 BAG domain + HSC70 ATPase domain - bovine<br />
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*'''BAG-2'''
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**[[3d0t]] – mBAG-2 BAG domain <br />
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*''BAG-2 complex with HSC70''
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**[[3cqx]] – mBAG-2 BAG domain + HSC70 ATPase domain <br />
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*'''BAG-4'''
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**[[1m62]], [[1m7k]] – hBAG-4 BAG domain - NMR<br />
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*'''BAG-5'''
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**[[1ugo]] – mBAG-5 BAG domain - NMR<br />
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**[[2d9d]] – hBAG-5 BAG domain - NMR<br />
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*''BAG-5 complex with HSC70''
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**[[3a8y]] – hBAG-5 BAG domain + HSC70 ATPase domain <br />
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*'''BAG-6'''
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**[[4eew]] – hBAG-6 UBL domain <br />
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**[[2n9p]] – hBAG-6 UBL domain + RNF126<br />
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**[[6au8]] – hBAG-6 residues 1008-1050 + TRC35 <br />
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**[[4wwr]], [[4x86]] – hBAG-6 residues 1054-1105 + ubiquitin-like protein 4A <br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry 3fzf)

Drag the structure with the mouse to rotate

References

  1. ↑ Kabbage M, Dickman MB. The BAG proteins: a ubiquitous family of chaperone regulators. Cell Mol Life Sci. 2008 May;65(9):1390-402. doi: 10.1007/s00018-008-7535-2. PMID:18264803 doi:http://dx.doi.org/10.1007/s00018-008-7535-2

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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