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2g76

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[[Image:2g76.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human 3-phosphoglycerate dehydrogenase==
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|PDB= 2g76 |SIZE=350|CAPTION= <scene name='initialview01'>2g76</scene>, resolution 1.70&Aring;
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<StructureSection load='2g76' size='340' side='right'caption='[[2g76]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MLT:MALATE+ION'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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<table><tr><td colspan='2'>[[2g76]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G76 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE= PHGDH, PGDH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [https://pdbe.org/2g76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB], [https://www.ebi.ac.uk/pdbsum/2g76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g76 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g76 OCA], [http://www.ebi.ac.uk/pdbsum/2g76 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g76 RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
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== Function ==
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[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g76_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g76 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human 3-phosphoglycerate dehydrogenase'''
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==See Also==
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*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2G76 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G76 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoglycerate dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Edwards A]]
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[[Category: Delft, F von.]]
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[[Category: Gileadi O]]
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[[Category: Edwards, A.]]
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[[Category: Oppermann U]]
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[[Category: Gileadi, O.]]
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[[Category: Salah E]]
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[[Category: Oppermann, U.]]
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[[Category: Savitsky P]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Salah, E.]]
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[[Category: Turnbull AP]]
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[[Category: Savitsky, P.]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Turnbull, A P.]]
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[[Category: Weigelt, J.]]
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[[Category: 2-hydroxyacid dehydrogenase]]
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[[Category: oxidoreductase]]
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[[Category: phosphoglycerate dehydrogenase deficiency]]
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[[Category: serine metabolism]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:43 2008''
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Current revision

Crystal structure of human 3-phosphoglycerate dehydrogenase

PDB ID 2g76

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