2g7r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:08, 6 November 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2g7r.gif|left|200px]]
 
-
{{Structure
+
==X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1==
-
|PDB= 2g7r |SIZE=350|CAPTION= <scene name='initialview01'>2g7r</scene>, resolution 2.70&Aring;
+
<StructureSection load='2g7r' size='340' side='right'caption='[[2g7r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2g7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G7R FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
|GENE= MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7r OCA], [https://pdbe.org/2g7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g7r RCSB], [https://www.ebi.ac.uk/pdbsum/2g7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7r ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Disease ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7r OCA], [http://www.ebi.ac.uk/pdbsum/2g7r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g7r RCSB]</span>
+
[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
-
}}
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
-
'''X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1'''
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
==About this Structure==
+
<jmolCheckbox>
-
2G7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7R OCA].
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7r_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g7r ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Bochkarev A]]
-
[[Category: Butler-Cole, C.]]
+
[[Category: Butler-Cole C]]
-
[[Category: Dhe-Paganon, S.]]
+
[[Category: Dhe-Paganon S]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Jr., P J.Finerty.]]
+
[[Category: Finerty Jr PJ]]
-
[[Category: Newman, E M.]]
+
[[Category: Newman EM]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Walker JR]]
-
[[Category: Walker, J R.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Wybenga-Groot L]]
-
[[Category: Wybenga-Groot, L.]]
+
-
[[Category: alternative splicing]]
+
-
[[Category: chromosomal translocation]]
+
-
[[Category: death domain]]
+
-
[[Category: hydrolase]]
+
-
[[Category: protease]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:57 2008''
+

Current revision

X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1

PDB ID 2g7r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2g7r"
Personal tools