2g8a

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[[Image:2g8a.gif|left|200px]]
 
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{{Structure
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==Lactobacillus casei Y261M in complex with substrate, dUMP==
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|PDB= 2g8a |SIZE=350|CAPTION= <scene name='initialview01'>2g8a</scene>, resolution 2.40&Aring;
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<StructureSection load='2g8a' size='340' side='right'caption='[[2g8a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=UMP:2&#39;-DEOXYURIDINE+5&#39;-MONOPHOSPHATE'>UMP</scene>
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<table><tr><td colspan='2'>[[2g8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8A FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE= thya ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1582 Lactobacillus casei])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8a OCA], [https://pdbe.org/2g8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8a RCSB], [https://www.ebi.ac.uk/pdbsum/2g8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8a ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2g86|2G86]], [[2g89|2G89]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8a OCA], [http://www.ebi.ac.uk/pdbsum/2g8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g8a RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8a ConSurf].
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<div style="clear:both"></div>
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'''Lactobacillus casei Y261M in complex with substrate, dUMP'''
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2G8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8A OCA].
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[[Category: Lacticaseibacillus casei]]
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[[Category: Lactobacillus casei]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Finer-Moore JS]]
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[[Category: Thymidylate synthase]]
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[[Category: Stroud RM]]
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[[Category: Finer-Moore, J S.]]
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[[Category: Stroud, R M.]]
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[[Category: active site mutation]]
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[[Category: alpha-beta protein]]
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[[Category: beta sheet]]
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[[Category: dump complex]]
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[[Category: methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:10 2008''
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Current revision

Lactobacillus casei Y261M in complex with substrate, dUMP

PDB ID 2g8a

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