1v2i

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==Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III==
==Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III==
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<StructureSection load='1v2i' size='340' side='right' caption='[[1v2i]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='1v2i' size='340' side='right'caption='[[1v2i]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1v2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V2I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1v2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respirovirus_3 Human respirovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V2I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2i OCA], [https://pdbe.org/1v2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v2i RCSB], [https://www.ebi.ac.uk/pdbsum/1v2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v2i OCA], [http://pdbe.org/1v2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v2i RCSB], [http://www.ebi.ac.uk/pdbsum/1v2i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v2i ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6WJ03_9MONO Q6WJ03_9MONO] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.[ARBA:ARBA00025476]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/1v2i_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/1v2i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Human respirovirus 3]]
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[[Category: Hpiv-3]]
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[[Category: Large Structures]]
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[[Category: Borg, N A]]
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[[Category: Borg NA]]
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[[Category: Colman, P M]]
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[[Category: Colman PM]]
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[[Category: Epa, V C]]
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[[Category: Epa VC]]
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[[Category: Lawrence, M C]]
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[[Category: Lawrence MC]]
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[[Category: McKimm-Breschkin, J L]]
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[[Category: McKimm-Breschkin JL]]
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[[Category: Pilling, P A]]
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[[Category: Pilling PA]]
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[[Category: Streltsov, V A]]
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[[Category: Streltsov VA]]
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[[Category: Varghese, J N]]
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[[Category: Varghese JN]]
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[[Category: Hydrolase]]
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[[Category: Native]]
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[[Category: Orthorhombic]]
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[[Category: Piv3 hn]]
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Current revision

Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III

PDB ID 1v2i

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Proteopedia Page Contributors and Editors (what is this?)

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