This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6g2n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6g2n is ON HOLD until Paper Publication Authors: Pachl, P., Rezacova, P., Brynda, J. Description: Crystal structure of human cytosolic 5'(3')-deoxy...) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU== | |
| - | + | <StructureSection load='6g2n' size='340' side='right' caption='[[6g2n]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g2n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O84:[(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic+acid'>O84</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g22|6g22]], [[6g2l|6g2l]], [[6g2m|6g2m]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2n OCA], [http://pdbe.org/6g2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2n RCSB], [http://www.ebi.ac.uk/pdbsum/6g2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2n ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NT5C_HUMAN NT5C_HUMAN]] Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Brynda, J]] | [[Category: Brynda, J]] | ||
[[Category: Pachl, P]] | [[Category: Pachl, P]] | ||
| + | [[Category: Rezacova, P]] | ||
| + | [[Category: 5'-nucleotidase]] | ||
| + | [[Category: Dephosphorylation]] | ||
| + | [[Category: Had-like]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Phosphorylation]] | ||
Current revision
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU
| |||||||||||
