6g2n
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6g2n is ON HOLD until Paper Publication Authors: Pachl, P., Rezacova, P., Brynda, J. Description: Crystal structure of human cytosolic 5'(3')-deoxy...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU== | |
| - | + | <StructureSection load='6g2n' size='340' side='right'caption='[[6g2n]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G2N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O84:[(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic+acid'>O84</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2n OCA], [https://pdbe.org/6g2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g2n RCSB], [https://www.ebi.ac.uk/pdbsum/6g2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2n ProSAT]</span></td></tr> |
| - | [[Category: Brynda | + | </table> |
| - | [[Category: Pachl | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NT5C_HUMAN NT5C_HUMAN] Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brynda J]] | ||
| + | [[Category: Pachl P]] | ||
| + | [[Category: Rezacova P]] | ||
Current revision
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU
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