From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | | + | #REDIRECT [[6dcn]] This PDB entry is obsolete and replaced by 6dcn |
| - | ==Bcl-xL complex with Beclin 1 BH3 domain T108pThr==
| + | |
| - | <StructureSection load='5vb1' size='340' side='right' caption='[[5vb1]], [[Resolution|resolution]] 2.44Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[5vb1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VB1 FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
| + | |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vax|5vax]], [[5vau|5vau]], [[5vay|5vay]], [[5vb4|5vb4]]</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vb1 OCA], [http://pdbe.org/5vb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vb1 RCSB], [http://www.ebi.ac.uk/pdbsum/5vb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vb1 ProSAT]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Fairlie, W D]]
| + | |
| - | [[Category: Lee, E F]]
| + | |
| - | [[Category: Smith, B J]]
| + | |
| - | [[Category: Yao, S]]
| + | |
| - | [[Category: Apoptosis]]
| + | |
| - | [[Category: Autophagy]]
| + | |
| - | [[Category: Bcl-2]]
| + | |
| - | [[Category: Beclin 1]]
| + | |
Current revision
- REDIRECT 6dcn This PDB entry is obsolete and replaced by 6dcn
