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5vb4

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#REDIRECT [[6dco]] This PDB entry is obsolete and replaced by 6dco
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==Bcl-xL complex with Beclin 1 BH3 domain T108D==
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<StructureSection load='5vb4' size='340' side='right' caption='[[5vb4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vb4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VB4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vax|5vax]], [[5vau|5vau]], [[5vb1|5vb1]], [[5vay|5vay]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vb4 OCA], [http://pdbe.org/5vb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5vb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vb4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Fairlie, W D]]
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[[Category: Lee, E F]]
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[[Category: Smith, B J]]
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[[Category: Yao, S]]
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[[Category: Apoptosis]]
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[[Category: Autophagy]]
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[[Category: Bcl-2]]
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[[Category: Beclin 1]]
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Current revision

  1. REDIRECT 6dco This PDB entry is obsolete and replaced by 6dco

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