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1psz

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PNEUMOCOCCAL SURFACE ANTIGEN PSAA

Structural highlights

1psz is a 1 chain structure with sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MTSA_STRPN Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Background:. The surface protein PsaA of the pathogenic bacterium Streptococcus pneumoniae plays an essential role in its virulence. PsaA is a putative ATP-binding cassette-type (ABC-type) binding protein involved in the uptake of Mn2+ and possibly Zn2+ and is considered to be both a potential drug target and and a candidate vaccine component. Results:. The structure of PsaA has been determined to 2.0 A resolution using X-ray crystallography and is the first structure obtained for an ABC-type binding protein from a Gram-positive organism. The protein consists of two (beta/alpha)4 domains linked together by a single helix. A metal-binding site is formed in the domain interface by the sidechains of His67, His139, Glu205 and Asp280 and is occupied in the structure. Conclusions:. The structural topology of PsaA is fundamentally different from that of other ABC-type binding proteins determined thus far in that PsaA lacks the characteristic 'hinge peptides' involved in conformational change upon solute uptake and release. In our structure, the metal-binding site is probably occupied by Zn2+. The site seems to be well conserved amongst related receptors from both Gram-positive and Gram-negative bacteria.

The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein.,Lawrence MC, Pilling PA, Epa VC, Berry AM, Ogunniyi AD, Paton JC Structure. 1998 Dec 15;6(12):1553-61. PMID:9862808^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lawrence MC, Pilling PA, Epa VC, Berry AM, Ogunniyi AD, Paton JC. The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein. Structure. 1998 Dec 15;6(12):1553-61. PMID:9862808

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1psz"

@@ Line 1: / Line 1: @@
 ==PNEUMOCOCCAL SURFACE ANTIGEN PSAA==
-<StructureSection load='1psz' size='340' side='right' caption='[[1psz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='1psz' size='340' side='right'caption='[[1psz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1psz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1psz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSZ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psz OCA], [http://pdbe.org/1psz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psz RCSB], [http://www.ebi.ac.uk/pdbsum/1psz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1psz ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psz OCA], [https://pdbe.org/1psz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psz RCSB], [https://www.ebi.ac.uk/pdbsum/1psz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psz ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MTSA_STRPN MTSA_STRPN]] Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.
+[https://www.uniprot.org/uniprot/MTSA_STRPN MTSA_STRPN] Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 31: @@
 ==See Also==
-*[[Adhesin|Adhesin]]
+*[[Adhesin 3D structures|Adhesin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Berry, A M]]
+[[Category: Large Structures]]
-[[Category: Epa, V C]]
+[[Category: Streptococcus pneumoniae]]
-[[Category: Lawrence, M C]]
+[[Category: Berry AM]]
-[[Category: Ogunniyi, A D]]
+[[Category: Epa VC]]
-[[Category: Paton, J C]]
+[[Category: Lawrence MC]]
-[[Category: Pilling, P A]]
+[[Category: Ogunniyi AD]]
-[[Category: Abc-type binding protein]]
+[[Category: Paton JC]]
-[[Category: Immune system]]
+[[Category: Pilling PA]]
-[[Category: Metal-binding protein]]
-[[Category: Pneumococcal surface antigen]]
-[[Category: Psaa]]

1psz

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Current revision

PNEUMOCOCCAL SURFACE ANTIGEN PSAA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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