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5wmm

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Current revision (14:17, 4 October 2023) (edit) (undo)
 
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==Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS==
==Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS==
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<StructureSection load='5wmm' size='340' side='right' caption='[[5wmm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='5wmm' size='340' side='right'caption='[[5wmm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wmm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Micromonospora_sp._ml1 Micromonospora sp. ml1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wmm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_sp._ML1 Micromonospora sp. ML1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WMM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6G:(2S)-2-amino-3-methylbutanoyl+(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl+hydrogen+(S)-phosphate'>B6G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tioS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349725 Micromonospora sp. ML1]), tioT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349725 Micromonospora sp. ML1])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B6G:(2S)-2-amino-3-methylbutanoyl+(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl+hydrogen+(S)-phosphate'>B6G</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmm OCA], [http://pdbe.org/5wmm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmm RCSB], [http://www.ebi.ac.uk/pdbsum/5wmm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmm OCA], [https://pdbe.org/5wmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wmm RCSB], [https://www.ebi.ac.uk/pdbsum/5wmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmm ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q333U7_9ACTN Q333U7_9ACTN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Micromonospora sp. ml1]]
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[[Category: Large Structures]]
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[[Category: Garneau-Tsodikova, S]]
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[[Category: Micromonospora sp. ML1]]
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[[Category: Mori, S]]
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[[Category: Garneau-Tsodikova S]]
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[[Category: Pang, A H]]
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[[Category: Mori S]]
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[[Category: Tsodikov, O V]]
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[[Category: Pang AH]]
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[[Category: Biosynthetic protein]]
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[[Category: Tsodikov OV]]
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[[Category: Depsipeptide]]
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[[Category: N-methylation]]
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[[Category: Nonribosomal peptide]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Thiocoraline]]
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[[Category: Thiolation]]
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Current revision

Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS

PDB ID 5wmm

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