2gku

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:36, 13 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gku.gif|left|200px]]
 
-
{{Structure
+
==Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures==
-
|PDB= 2gku |SIZE=350|CAPTION= <scene name='initialview01'>2gku</scene>
+
<StructureSection load='2gku' size='340' side='right'caption='[[2gku]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+
<table><tr><td colspan='2'>[[2gku]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GKU FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [https://pdbe.org/2gku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB], [https://www.ebi.ac.uk/pdbsum/2gku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gku ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=[[143d|143D]], [[186d|186D]], [[1k8p|1K8P]], [[2aqy|2AQY]]
+
<div style="background-color:#fffaf0;">
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [http://www.ebi.ac.uk/pdbsum/2gku PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB]</span>
+
== Publication Abstract from PubMed ==
-
}}
+
-
 
+
-
'''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures'''
+
-
 
+
-
 
+
-
==Overview==
+
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
-
==About this Structure==
+
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.,Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556<ref>PMID:16866556</ref>
-
2GKU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16866556 16866556]
+
</div>
 +
<div class="pdbe-citations 2gku" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Kuryavyi, V V.]]
+
[[Category: Kuryavyi VV]]
-
[[Category: Lacroix, L.]]
+
[[Category: Lacroix L]]
-
[[Category: Luu, K N.]]
+
[[Category: Luu KN]]
-
[[Category: Patel, D J.]]
+
[[Category: Patel DJ]]
-
[[Category: Phan, A T.]]
+
[[Category: Phan AT]]
-
[[Category: 3+1 strand folding;edgewise]]
+
-
[[Category: double-chain reversal loop]]
+
-
[[Category: g-tetrad]]
+
-
[[Category: nmr,12 structure]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:02 2008''
+

Current revision

Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures

PDB ID 2gku

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gku"
Personal tools