2glw

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[[Image:2glw.gif|left|200px]]
 
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{{Structure
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==The solution structure of PHS018 from pyrococcus horikoshii==
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|PDB= 2glw |SIZE=350|CAPTION= <scene name='initialview01'>2glw</scene>
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<StructureSection load='2glw' size='340' side='right'caption='[[2glw]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2glw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GLW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= PHS018 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2glw OCA], [https://pdbe.org/2glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2glw RCSB], [https://www.ebi.ac.uk/pdbsum/2glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2glw ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2glw OCA], [http://www.ebi.ac.uk/pdbsum/2glw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2glw RCSB]</span>
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[https://www.uniprot.org/uniprot/O73971_PYRHO O73971_PYRHO]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''The solution structure of PHS018 from pyrococcus horikoshii'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/2glw_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2glw ConSurf].
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2GLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Common evolutionary origin of swapped-hairpin and double-psi beta barrels., Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, Lupas AN, Structure. 2006 Oct;14(10):1489-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17027498 17027498]
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[[Category: Large Structures]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Single protein]]
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[[Category: Coles M]]
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[[Category: Coles, M.]]
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[[Category: Hulko M]]
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[[Category: Hulko, M.]]
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[[Category: Lupas AN]]
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[[Category: Lupas, A N.]]
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[[Category: Martin J]]
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[[Category: Martin, J.]]
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[[Category: Truffault V]]
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[[Category: Truffault, V.]]
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[[Category: bioinformatic]]
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[[Category: nmr]]
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[[Category: rift barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:22 2008''
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Current revision

The solution structure of PHS018 from pyrococcus horikoshii

PDB ID 2glw

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