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2gm8

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[[Image:2gm8.gif|left|200px]]
 
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{{Structure
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==TenA Homolog/Thi-4 Thiaminase complexed with product 4-amino-5-hydroxymethyl-2-methylpyrimidine==
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|PDB= 2gm8 |SIZE=350|CAPTION= <scene name='initialview01'>2gm8</scene>, resolution 2.500&Aring;
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<StructureSection load='2gm8' size='340' side='right'caption='[[2gm8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HMH:4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE'>HMH</scene>
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<table><tr><td colspan='2'>[[2gm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._IM2 Pyrobaculum aerophilum str. IM2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GM8 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine_pyridinylase Thiamine pyridinylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.2 2.5.1.2] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE= tenA/thi4 (pag5_170) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=178306 Pyrobaculum aerophilum str. IM2])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HMH:4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE'>HMH</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gm8 OCA], [https://pdbe.org/2gm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gm8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gm8 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2gm7|2GM7]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gm8 OCA], [http://www.ebi.ac.uk/pdbsum/2gm8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gm8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q8ZZM9_PYRAE Q8ZZM9_PYRAE]
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== Evolutionary Conservation ==
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'''TenA Homolog/Thi-4 Thiaminase complexed with product 4-amino-5-hydroxymethyl-2-methylpyrimidine'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/2gm8_consurf.spt"</scriptWhenChecked>
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2GM8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum_str._im2 Pyrobaculum aerophilum str. im2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GM8 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Pyrobaculum aerophilum str. im2]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Thiamine pyridinylase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gm8 ConSurf].
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[[Category: Chan, S.]]
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<div style="clear:both"></div>
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[[Category: Han, G W.]]
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__TOC__
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[[Category: Pashkov, I.]]
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</StructureSection>
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[[Category: Perry, L J.]]
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[[Category: Large Structures]]
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[[Category: Sawaya, M R.]]
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[[Category: Pyrobaculum aerophilum str. IM2]]
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[[Category: thiaminase]]
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[[Category: Chan S]]
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[[Category: transcription]]
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[[Category: Han GW]]
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[[Category: Pashkov I]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:31 2008''
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[[Category: Perry LJ]]
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[[Category: Sawaya MR]]

Current revision

TenA Homolog/Thi-4 Thiaminase complexed with product 4-amino-5-hydroxymethyl-2-methylpyrimidine

PDB ID 2gm8

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