Calcium/Calmodulin-dependent protein kinase

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== Function ==
== Function ==
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[[Ca2+/Calmodulin dependent protein kinase]] (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br />
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Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. <br />
*'''CaMKI''' is a specialized CaM kinase.<br />
*'''CaMKI''' is a specialized CaM kinase.<br />
*'''CaMKII''' is multifunctional kinase. <br />
*'''CaMKII''' is multifunctional kinase. <br />
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CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>
CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). DAPK contains a regulatory (RD) and autoinhibitory (AD) domains. The activity of human CamKII is regulated by autophosphorylation of <scene name='41/415817/Cv/3'>Thr 286</scene> and Thr 305 (T305 is not in the pdb file). <ref>PMID:20668654</ref>
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</StructureSection>
 
== 3D Structures of Calcium/calmodulin dependent protein kinase ==
== 3D Structures of Calcium/calmodulin dependent protein kinase ==
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[[Calcium/calmodulin dependent protein kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* CaMKI – specialized CaM kinase
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**[[1a06]] – rCaMK - rat<br />
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**[[4fgb]] – hCaMKI - human<br />
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**[[4fg9]], [[4fg8]], [[4fg7]] – hCaMKI + ATP<br />
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**[[2jam]] - hCaMKI kinase domain +peptides <br />
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* CASK – membrane-associated CaMK
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**[[3mfr]] – hCASK CBD <br />
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**[[3mfs]] – hCASK+AMPPNP<br />
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**[[3mft]] – hCASK+Mn<br />
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**[[3c0g]] – hCASK kinase domain<br />
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**[[3c0h]] - hCASK kinase domain+AMPPNP<br />
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**[[3c0i]] - hCASK kinase domain+AMP<br />
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**[[3tac]] – hCASK kinase domain + liprin-α-2<br />
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**[[3mfu]] - hCASK+AMPPNP+Mn<br />
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* DAPK – death-associated CaMK
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**[[2x0g]] – hDAPK RD+AD+CaM<br />
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**[[2cke]] – hDAPK+inhibitor<br />
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* CaMKII – multifunctional CaM kinase
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**[[3kk9]], [[3kk8]] - hCaMKII kinase domain<br />
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**[[3soa]] - hCaMKII (mutant)<br />
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**[[3kl8]] - hCaMKII (mutant) + inhibitor<br />
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**[[5ig3]] - hCaMKII α chain<br />
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**[[5hu3]], [[5h9b]], [[5fg8]] - hCaMKII α chain + potassium channel protein EAG<br />
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**[[2vz6]] - hCaMKII α + indirubin-E804<br />
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**[[3bhh]] - hCaMKII β <br />
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**[[2zv2]] – hCaMKII β +STO-609<br />
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**[[2v7o]] - hCaMKII γ <br />
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**[[2ux0]] - hCaMKII γ (mutant) <br />
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**[[2wel]] - hCaMKII δ + CaM<br />
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**[[2w2c]] - hCaMKII δ oligomerization domain<br />
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**[[2vn9]] - hCaMKII δ <br />
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**[[2jc6]] - hCaMKII δ <br />
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**[[6ayw]], [[5vlo]] - hCaMKII δ chain + inhibitor<br />
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**[[1hkx]] - mCaMKII α - mouse<br />
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**[[6bab]] - mCaMKII δ chain + inhibitor<br />
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**[[5u6y]] - rCaMKII α chain<br />
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**[[3gp2]] – cCaMKII δ + CaM – chicken<br />
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* CaMKIV
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**[[2w4o]] – hCaMKIV+inhibitor<br />
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}}
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human CamKII subunit α kinase domain complex with indirubin (PDB code 2vz6)

Drag the structure with the mouse to rotate

References

  1. ↑ Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654 doi:10.1371/journal.pbio.1000426

See Calcium-dependent protein kinase

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Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky

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