2gom

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:28, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gom.jpg|left|200px]]
 
-
{{Structure
+
==Crystal structure of Efb-C from Staphylococcus aureus==
-
|PDB= 2gom |SIZE=350|CAPTION= <scene name='initialview01'>2gom</scene>, resolution 1.25&Aring;
+
<StructureSection load='2gom' size='340' side='right'caption='[[2gom]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
-
|GENE= efb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=[[2gox|2GOX]]
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [http://www.ebi.ac.uk/pdbsum/2gom PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB]</span>
+
[https://www.uniprot.org/uniprot/FIB_STAAM FIB_STAAM] Binds to host fibrinogen (By similarity).
-
}}
+
-
'''Crystal structure of Efb-C from Staphylococcus aureus'''
+
==See Also==
-
 
+
*[[Fibrinogen binding protein|Fibrinogen binding protein]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.
+
[[Category: Large Structures]]
-
 
+
[[Category: Staphylococcus aureus subsp. aureus Mu50]]
-
==About this Structure==
+
[[Category: Geisbrecht BV]]
-
2GOM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA].
+
[[Category: Hammel M]]
-
 
+
-
==Reference==
+
-
A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17351618 17351618]
+
-
[[Category: Single protein]]
+
-
[[Category: Staphylococcus aureus]]
+
-
[[Category: Geisbrecht, B V.]]
+
-
[[Category: Hammel, M.]]
+
-
[[Category: three-helix closed bundle with left-hand twist]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:19:27 2008''
+

Current revision

Crystal structure of Efb-C from Staphylococcus aureus

PDB ID 2gom

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gom"
Personal tools