6csb

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'''Unreleased structure'''
 
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The entry 6csb is ON HOLD until Paper Publication
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==V308E mutant of cytochrome P450 2D6 complexed with thioridazine==
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<StructureSection load='6csb' size='340' side='right'caption='[[6csb]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6csb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CSB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.394&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RTZ:10-{2-[(2R)-1-METHYLPIPERIDIN-2-YL]ETHYL}-2-(METHYLSULFANYL)-10H-PHENOTHIAZINE'>RTZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csb OCA], [https://pdbe.org/6csb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6csb RCSB], [https://www.ebi.ac.uk/pdbsum/6csb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6csb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref>
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Authors:
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fujita K]]
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[[Category: Im SC]]
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[[Category: Meagher J]]
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[[Category: Pearl NM]]
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[[Category: Stuckey J]]
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[[Category: Wang PF]]
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[[Category: Waskell L]]
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[[Category: Yang YT]]

Current revision

V308E mutant of cytochrome P450 2D6 complexed with thioridazine

PDB ID 6csb

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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