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6cxw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Synaptotagmin 1 C2A beta4 chimera with enhanced PIP2 binding function== | |
| + | <StructureSection load='6cxw' size='340' side='right'caption='[[6cxw]], [[Resolution|resolution]] 1.83Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6cxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CXW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.832Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxw OCA], [https://pdbe.org/6cxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cxw RCSB], [https://www.ebi.ac.uk/pdbsum/6cxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | ||
| - | + | ==See Also== | |
| - | + | *[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Sutton | + | [[Category: Large Structures]] |
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Sutton RB]] | ||
Current revision
Synaptotagmin 1 C2A beta4 chimera with enhanced PIP2 binding function
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