2grl

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[[Image:2grl.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of dCT/iCF10 complex==
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|PDB= 2grl |SIZE=350|CAPTION= <scene name='initialview01'>2grl</scene>, resolution 3.00&Aring;
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<StructureSection load='2grl' size='340' side='right'caption='[[2grl]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2grl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRL FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2grl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grl OCA], [https://pdbe.org/2grl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2grl RCSB], [https://www.ebi.ac.uk/pdbsum/2grl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2grl ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[2grm|2GRM]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grl OCA], [http://www.ebi.ac.uk/pdbsum/2grl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2grl RCSB]</span>
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[https://www.uniprot.org/uniprot/Q04114_ENTFL Q04114_ENTFL]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal structure of dCT/iCF10 complex'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grl_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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In many bacteria expression of lateral gene transfer and of virulence factors is controlled by cell-cell signalling systems. Molecular interactions of microbial signal molecules with their cognate receptors are not well understood. For the Enterococcus faecalis conjugative plasmid pCF10, the PrgX protein serves as a molecular switch controlling expression of conjugation and virulence genes encoded by the plasmid. The induction state of a pCF10-carrying donor cell is determined by the ratio of two signalling peptides, cCF10 pheromone and iCF10 inhibitor. Recent analysis of PrgX/cCF10 interactions suggests a mechanism for conversion to the induced state. However, the means by which iCF10 peptide antagonizes cCF10 activity is unclear, and it has been suggested that inhibitor peptides block import of pheromone peptides. We now show that both of these peptides interact with the same binding pocket of PrgX, but they differentially alter the conformation of the protein and its oligomerization state, resulting in opposing biological activities.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2grl ConSurf].
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2GRL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRL OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides., Kozlowicz BK, Shi K, Gu ZY, Ohlendorf DH, Earhart CA, Dunny GM, Mol Microbiol. 2006 Nov;62(4):958-69. Epub 2006 Oct 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17038121 17038121]
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[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dunny, G M.]]
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[[Category: Dunny GM]]
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[[Category: Earhart, C A.]]
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[[Category: Earhart CA]]
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[[Category: Gu, Z Y.]]
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[[Category: Gu ZY]]
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[[Category: Kozlowicz, B K.]]
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[[Category: Kozlowicz BK]]
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[[Category: Ohlendorf, D H.]]
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[[Category: Ohlendorf DH]]
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[[Category: Shi, K.]]
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[[Category: Shi K]]
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[[Category: inhibitor]]
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[[Category: receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:20:32 2008''
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Current revision

Crystal structure of dCT/iCF10 complex

PDB ID 2grl

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