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6bxl

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==Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and SAM==
==Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and SAM==
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<StructureSection load='6bxl' size='340' side='right' caption='[[6bxl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='6bxl' size='340' side='right'caption='[[6bxl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bxl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-(3-amino-3-carboxypropyl)histidine_synthase 2-(3-amino-3-carboxypropyl)histidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.108 2.5.1.108] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxl OCA], [http://pdbe.org/6bxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxl RCSB], [http://www.ebi.ac.uk/pdbsum/6bxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxl OCA], [https://pdbe.org/6bxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxl RCSB], [https://www.ebi.ac.uk/pdbsum/6bxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPH2_PYRHO DPH2_PYRHO]] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).<ref>PMID:20559380</ref>
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[https://www.uniprot.org/uniprot/DPH2_PYRHO DPH2_PYRHO] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).<ref>PMID:20559380</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carantoa, J D]]
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[[Category: Large Structures]]
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[[Category: Dong, M]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Dzikovski, B]]
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[[Category: Carantoa JD]]
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[[Category: Ealick, S E]]
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[[Category: Dong M]]
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[[Category: Fenwick, M K]]
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[[Category: Dzikovski B]]
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[[Category: Freed, J H]]
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[[Category: Ealick SE]]
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[[Category: Hoffman, B M]]
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[[Category: Fenwick MK]]
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[[Category: Kathiresan, V]]
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[[Category: Freed JH]]
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[[Category: Lancaster, K M]]
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[[Category: Hoffman BM]]
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[[Category: Lin, H]]
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[[Category: Kathiresan V]]
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[[Category: Torelli, A T]]
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[[Category: Lancaster KM]]
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[[Category: Zhang, Y]]
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[[Category: Lin H]]
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[[Category: Biosynthetic protein]]
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[[Category: Torelli AT]]
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[[Category: Diphthamide biosynthesis]]
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[[Category: Zhang Y]]
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[[Category: Radical sam enzyme]]
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Current revision

Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and SAM

PDB ID 6bxl

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