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6ffc
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==Structure of an inhibitor-bound ABC transporter== | ==Structure of an inhibitor-bound ABC transporter== | ||
| - | < | + | <SX load='6ffc' size='340' side='right' viewer='molstar' caption='[[6ffc]], [[Resolution|resolution]] 3.56Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6ffc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFC OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6ffc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FFC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWQ:~{tert}-butyl+3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate'>BWQ</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.56Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BWQ:~{tert}-butyl+3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate'>BWQ</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ffc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffc OCA], [https://pdbe.org/6ffc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ffc RCSB], [https://www.ebi.ac.uk/pdbsum/6ffc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ABCG2_HUMAN ABCG2_HUMAN] High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.<ref>PMID:12958161</ref> <ref>PMID:20705604</ref> <ref>PMID:22132962</ref> <ref>PMID:23189181</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6ffc" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6ffc" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[ABC transporter 3D structures|ABC transporter 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: Altmann | + | [[Category: Homo sapiens]] |
| - | [[Category: Bartholomaeus | + | [[Category: Large Structures]] |
| - | [[Category: Bauer | + | [[Category: Altmann KH]] |
| - | [[Category: Bause | + | [[Category: Bartholomaeus R]] |
| - | [[Category: Bernhardt | + | [[Category: Bauer S]] |
| - | [[Category: Buschauer | + | [[Category: Bause M]] |
| - | [[Category: Jackson | + | [[Category: Bernhardt G]] |
| - | [[Category: Koenig | + | [[Category: Buschauer A]] |
| - | [[Category: Kowal | + | [[Category: Jackson SM]] |
| - | [[Category: Locher | + | [[Category: Koenig B]] |
| - | [[Category: Manolaridis | + | [[Category: Kowal J]] |
| - | [[Category: Stahlberg | + | [[Category: Locher KP]] |
| - | [[Category: Taylor | + | [[Category: Manolaridis I]] |
| - | [[Category: Zechner | + | [[Category: Stahlberg H]] |
| - | + | [[Category: Taylor NMI]] | |
| - | + | [[Category: Zechner M]] | |
Current revision
Structure of an inhibitor-bound ABC transporter
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Categories: Homo sapiens | Large Structures | Altmann KH | Bartholomaeus R | Bauer S | Bause M | Bernhardt G | Buschauer A | Jackson SM | Koenig B | Kowal J | Locher KP | Manolaridis I | Stahlberg H | Taylor NMI | Zechner M
