2gsh

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[[Image:2gsh.gif|left|200px]]
 
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{{Structure
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==Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium==
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|PDB= 2gsh |SIZE=350|CAPTION= <scene name='initialview01'>2gsh</scene>, resolution 2.393&Aring;
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<StructureSection load='2gsh' size='340' side='right'caption='[[2gsh]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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<table><tr><td colspan='2'>[[2gsh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSH FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-rhamnonate_dehydratase L-rhamnonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.90 4.2.1.90] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.393&#8491;</td></tr>
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|GENE= STM2291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 COG4948], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03327 MR_like_2]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsh OCA], [https://pdbe.org/2gsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsh RCSB], [https://www.ebi.ac.uk/pdbsum/2gsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsh ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2gsh TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsh OCA], [http://www.ebi.ac.uk/pdbsum/2gsh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gsh RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RHMD_SALTY RHMD_SALTY] Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.<ref>PMID:18754693</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsh_consurf.spt"</scriptWhenChecked>
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2GSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSH OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: L-rhamnonate dehydratase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Salmonella typhimurium]]
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</jmolCheckbox>
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[[Category: Single protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsh ConSurf].
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[[Category: Adams, J M.]]
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<div style="clear:both"></div>
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[[Category: Almo, S C.]]
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== References ==
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[[Category: Burley, S K.]]
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<references/>
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[[Category: Dickey, M.]]
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__TOC__
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[[Category: Gerlt, J.]]
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</StructureSection>
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[[Category: Malashkevich, V N.]]
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[[Category: Large Structures]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Patskovsky, Y.]]
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[[Category: Adams JM]]
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[[Category: Sauder, J M.]]
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[[Category: Almo SC]]
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[[Category: Wasserman, S R.]]
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[[Category: Burley SK]]
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[[Category: enolase]]
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[[Category: Dickey M]]
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[[Category: new york structural genomix research consortium]]
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[[Category: Gerlt J]]
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[[Category: nysgxrc]]
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[[Category: Malashkevich VN]]
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[[Category: protein structure initiative]]
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[[Category: Patskovsky Y]]
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[[Category: psi]]
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[[Category: Sauder JM]]
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[[Category: structural genomic]]
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[[Category: Wasserman SR]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:20:54 2008''
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Current revision

Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium

PDB ID 2gsh

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