6bf9

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==Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain==
==Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain==
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<StructureSection load='6bf9' size='340' side='right' caption='[[6bf9]], [[Resolution|resolution]] 7.20&Aring;' scene=''>
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<SX load='6bf9' size='340' side='right' viewer='molstar' caption='[[6bf9]], [[Resolution|resolution]] 7.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bf9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bf9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BF9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b70|6b70]], [[6b3q|6b3q]], [[6b7y|6b7y]], [[6b7z|6b7z]], [[6bf6|6bf6]], [[6bf7|6bf7]], [[6bf8|6bf8]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf9 OCA], [https://pdbe.org/6bf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bf9 RCSB], [https://www.ebi.ac.uk/pdbsum/6bf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf9 OCA], [http://pdbe.org/6bf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf9 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6bf9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6bf9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Insulysin]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Bailey, L J]]
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[[Category: Bailey LJ]]
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[[Category: Carragher, B]]
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[[Category: Carragher B]]
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[[Category: Kossiakoff, A A]]
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[[Category: Kossiakoff AA]]
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[[Category: Liang, W G]]
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[[Category: Liang WG]]
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[[Category: Potter, S C]]
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[[Category: Potter SC]]
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[[Category: Tan, Y Z]]
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[[Category: Tan YZ]]
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[[Category: Tang, W J]]
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[[Category: Tang WJ]]
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[[Category: Wei, H]]
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[[Category: Wei H]]
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[[Category: Zhang, Z]]
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[[Category: Zhang Z]]
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[[Category: Amyloid beta]]
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[[Category: Hydrolase-immune system complex]]
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[[Category: Ide]]
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Current revision

Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain

6bf9, resolution 7.20Å

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OCA

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