1whd
From Proteopedia
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==Solution structure of the PDZ domain of RGS3== | ==Solution structure of the PDZ domain of RGS3== | ||
| - | <StructureSection load='1whd' size='340' side='right' caption='[[1whd | + | <StructureSection load='1whd' size='340' side='right'caption='[[1whd]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1whd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1whd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHD FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whd OCA], [https://pdbe.org/1whd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whd RCSB], [https://www.ebi.ac.uk/pdbsum/1whd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whd ProSAT], [https://www.topsan.org/Proteins/RSGI/1whd TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RGS3_MOUSE RGS3_MOUSE] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:11301003</ref> <ref>PMID:12210723</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Regulator of G protein signaling|Regulator of G protein signaling]] | + | *[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Inoue | + | [[Category: Mus musculus]] |
| - | [[Category: Kigawa | + | [[Category: Inoue M]] |
| - | [[Category: Koshiba | + | [[Category: Kigawa T]] |
| - | [[Category: Nakanishi | + | [[Category: Koshiba S]] |
| - | [[Category: Nemoto | + | [[Category: Nakanishi T]] |
| - | + | [[Category: Nemoto N]] | |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of the PDZ domain of RGS3
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Categories: Large Structures | Mus musculus | Inoue M | Kigawa T | Koshiba S | Nakanishi T | Nemoto N | Yokoyama S
