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1wxa

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==Solution Structure of Ras-binding Domain in Mouse AF-6 Protein==
==Solution Structure of Ras-binding Domain in Mouse AF-6 Protein==
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<StructureSection load='1wxa' size='340' side='right' caption='[[1wxa]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wxa' size='340' side='right'caption='[[1wxa]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WXA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 4932441D06 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxa OCA], [http://pdbe.org/1wxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wxa RCSB], [http://www.ebi.ac.uk/pdbsum/1wxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxa ProSAT], [http://www.topsan.org/Proteins/RSGI/1wxa TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxa OCA], [https://pdbe.org/1wxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxa RCSB], [https://www.ebi.ac.uk/pdbsum/1wxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxa ProSAT], [https://www.topsan.org/Proteins/RSGI/1wxa TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AFAD_MOUSE AFAD_MOUSE]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.<ref>PMID:10477764</ref>
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[https://www.uniprot.org/uniprot/AFAD_MOUSE AFAD_MOUSE] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.<ref>PMID:10477764</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Mus musculus]]
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[[Category: Kigawa, T]]
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[[Category: Inoue M]]
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[[Category: Koshiba, S]]
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[[Category: Kigawa T]]
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[[Category: Structural genomic]]
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[[Category: Koshiba S]]
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[[Category: Tomizawa, T]]
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[[Category: Tomizawa T]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Zhao, C]]
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[[Category: Zhao C]]
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[[Category: Af-6 protein]]
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[[Category: Afadin]]
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[[Category: Cell adhesion]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Ras-binding domain]]
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[[Category: Rsgi]]
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[[Category: Ubiquitin-like fold]]
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Current revision

Solution Structure of Ras-binding Domain in Mouse AF-6 Protein

PDB ID 1wxa

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