This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1x57
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Solution structures of the HTH domain of human EDF-1 protein== | ==Solution structures of the HTH domain of human EDF-1 protein== | ||
| - | <StructureSection load='1x57' size='340' side='right' caption='[[1x57 | + | <StructureSection load='1x57' size='340' side='right'caption='[[1x57]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x57]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1x57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X57 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x57 OCA], [https://pdbe.org/1x57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x57 RCSB], [https://www.ebi.ac.uk/pdbsum/1x57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x57 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x57 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/EDF1_HUMAN EDF1_HUMAN] Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.<ref>PMID:9813014</ref> <ref>PMID:10567391</ref> <ref>PMID:12040021</ref> <ref>PMID:15112053</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 23: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Inoue | + | [[Category: Large Structures]] |
| - | [[Category: Kigawa | + | [[Category: Inoue M]] |
| - | [[Category: Koshiba | + | [[Category: Kigawa T]] |
| - | [[Category: Nameki | + | [[Category: Koshiba S]] |
| - | + | [[Category: Nameki N]] | |
| - | [[Category: Sato | + | [[Category: Sato M]] |
| - | [[Category: Tochio | + | [[Category: Tochio N]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structures of the HTH domain of human EDF-1 protein
| |||||||||||
Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Nameki N | Sato M | Tochio N | Yokoyama S
