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1wyr
From Proteopedia
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==Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6== | ==Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6== | ||
| - | <StructureSection load='1wyr' size='340' side='right' caption='[[1wyr | + | <StructureSection load='1wyr' size='340' side='right'caption='[[1wyr]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1wyr]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1wyr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WYR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wyr OCA], [https://pdbe.org/1wyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wyr RCSB], [https://www.ebi.ac.uk/pdbsum/1wyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wyr ProSAT], [https://www.topsan.org/Proteins/RSGI/1wyr TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Rho guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor]] | + | *[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Inoue M]] |
| - | [[Category: | + | [[Category: Kigawa T]] |
| - | [[Category: | + | [[Category: Koshiba S]] |
| - | [[Category: Tomizawa | + | [[Category: Tomizawa T]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
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Current revision
Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6
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