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2gyz

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[[Image:2gyz.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human artemin==
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|PDB= 2gyz |SIZE=350|CAPTION= <scene name='initialview01'>2gyz</scene>, resolution 1.76&Aring;
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<StructureSection load='2gyz' size='340' side='right'caption='[[2gyz]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2gyz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GYZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gyz OCA], [https://pdbe.org/2gyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gyz RCSB], [https://www.ebi.ac.uk/pdbsum/2gyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gyz ProSAT]</span></td></tr>
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|GENE=
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</table>
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|DOMAIN=
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== Function ==
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|RELATEDENTRY=
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[[https://www.uniprot.org/uniprot/ARTN_HUMAN ARTN_HUMAN]] Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.<ref>PMID:9883723</ref> <ref>PMID:10583383</ref>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gyz OCA], [http://www.ebi.ac.uk/pdbsum/2gyz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gyz RCSB]</span>
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== Evolutionary Conservation ==
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}}
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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'''Crystal structure of human artemin'''
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/2gyz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==Overview==
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gyz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications.
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications.
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==About this Structure==
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Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.,Wang X, Baloh RH, Milbrandt J, Garcia KC Structure. 2006 Jun;14(6):1083-92. PMID:16765900<ref>PMID:16765900</ref>
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2GYZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GYZ OCA].
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==Reference==
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Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors., Wang X, Baloh RH, Milbrandt J, Garcia KC, Structure. 2006 Jun;14(6):1083-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16765900 16765900]
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Garcia, K C.]]
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[[Category: Wang, X Q.]]
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[[Category: cystine-knot]]
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[[Category: neurotrophic factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:23:10 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2gyz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Garcia, K C]]
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[[Category: Wang, X Q]]
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[[Category: Cystine-knot]]
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[[Category: Hormone-growth factor complex]]
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[[Category: Neurotrophic factor]]

Current revision

Crystal structure of human artemin

PDB ID 2gyz

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