6d0c

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(New page: '''Unreleased structure''' The entry 6d0c is ON HOLD Authors: Du, X. Description: Crystal structure of HIF2a-B*:ARNT-B* complex Category: Unreleased Structures Category: Du, X)
Current revision (15:14, 4 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6d0c is ON HOLD
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==Crystal structure of HIF2a-B*:ARNT-B* complex==
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<StructureSection load='6d0c' size='340' side='right'caption='[[6d0c]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6d0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D0C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0c OCA], [https://pdbe.org/6d0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d0c RCSB], [https://www.ebi.ac.uk/pdbsum/6d0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/EPAS1_HUMAN EPAS1_HUMAN] Defects in EPAS1 are the cause of familial erythrocytosis type 4 (ECYT4) [MIM:[https://omim.org/entry/611783 611783]. ECYT4 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin concentration and hematocrit, and normal platelet and leukocyte counts.<ref>PMID:19208626</ref> <ref>PMID:18378852</ref> <ref>PMID:18184961</ref> <ref>PMID:22367913</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/EPAS1_HUMAN EPAS1_HUMAN] Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
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Authors: Du, X.
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==See Also==
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*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
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Description: Crystal structure of HIF2a-B*:ARNT-B* complex
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Du, X]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Du X]]

Current revision

Crystal structure of HIF2a-B*:ARNT-B* complex

PDB ID 6d0c

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