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6d0h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS== | |
| - | + | <StructureSection load='6d0h' size='340' side='right'caption='[[6d0h]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d0h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_sp._YBL2 Sphingobium sp. YBL2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D0H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d0h OCA], [https://pdbe.org/6d0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d0h RCSB], [https://www.ebi.ac.uk/pdbsum/6d0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d0h ProSAT]</span></td></tr> |
| - | [[Category: Link | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PART_SPHYB PART_SPHYB] Toxic component of a type II toxin-antitoxin (TA) system. Expression in E.coli inhibits cell growth; bacteriostasis is neutralized by expression of cognate antitoxin ParS. ADP-ribosylates E.coli ribose-phosphate pyrophosphokinase (RPPK, prs) using NAD(+) in vitro; ADP-ribosylates RPPK on 'Lys-182' and 'Ser-202'. Cannot use NADP(+). Also auto-ADP-ribosylates in vitro; in the presence of RPPK auto-ADP-ribosylation decreases.<ref>PMID:30598453</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sphingobium sp. YBL2]] | ||
| + | [[Category: Jeffrey PD]] | ||
| + | [[Category: Link AJ]] | ||
| + | [[Category: Piscotta FJ]] | ||
Current revision
ParT: Prs ADP-ribosylating toxin bound to cognate antitoxin ParS
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