6d1t

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m (Protected "6d1t" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6d1t is ON HOLD
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==Complex of MBD1-MBD and methylated DNA==
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<StructureSection load='6d1t' size='340' side='right'caption='[[6d1t]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6d1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D1T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1t OCA], [https://pdbe.org/6d1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d1t RCSB], [https://www.ebi.ac.uk/pdbsum/6d1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref>
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Authors: Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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Description: Complex of MBD1-MBD and methylated DNA
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Arrowsmith, C.H]]
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__TOC__
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[[Category: Xu, C]]
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</StructureSection>
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[[Category: Liu, K]]
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[[Category: Homo sapiens]]
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[[Category: Min, J]]
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[[Category: Large Structures]]
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[[Category: Edwards, A.M]]
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[[Category: Synthetic construct]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Tempel, W]]
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[[Category: Edwards AM]]
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[[Category: Liu K]]
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[[Category: Min J]]
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[[Category: Tempel W]]
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[[Category: Xu C]]

Current revision

Complex of MBD1-MBD and methylated DNA

PDB ID 6d1t

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